ビタミンB_1代謝および肝機能にたいする自律神経遮断剤の影響について

概要

論文の詳細を見る
Judging from the fact, that the transitions of thiamine concentration in blood and of thiamine excretion into urine after the loading of thiamine are greatly influenced by the previous administration of Finalin (diethylaminoethyl diphenylglycolate methobromide), it is deduced that thiamine metabolism is closely related to the autonomic nerve system. A series of experiments was made to study this relation. Parasympathetic nerve blocking agents (e.g.Finalin) facilitate the preservation of thiamine in liver, and restrain its urinary excretion. In case that parasympathetic nerve stimulating agent (acetylcholine) or sympathetic nerve blocking agent (Pentamethonium) is administered to mice in advance, and that the liver is incubated in vitro with thiamine, destruction of thiamine is seen. On the contrary, in case that parasympathetic nerve blocking agents (Atropine or Finalin) are administered in advance and that the liver is incubated in vitro with thiamine, no destruction of thiamine, but the increase of total thiamine is observed.
日本ビタミン学会の論文