放射性コバルト全身照射とビタミンB_2代謝に関する実験的研究 : (IV)Co^<60>全身照射シロネズミのビタミンB_2の分布の変動に及ぼすビタミンB_2の影響について

概要

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The riboflavin administered rats were exposed to 2000 r of γ-ray from Co^<60>. One group of the rats had been under a daily subcutaneous injection of 0.5 μg of the vitamin before irradiation. The others were kept under the administration even after irradiation. In the non-irradiated and vitamin administered group, the riboflavin content of a unit weight of the organs was increased in the small intestine, kidney, liver, stomach in that order. Likewise, increase of the urinary and feceal excretion of the vitamin, was observed. It was found that the administration of riboflavin before irradiation lessened the fluctuation of the vitamin distribution caused by the irradiation. Thus, a postulation was made that the administration of riboflavin before irradiation might improve the radiation sickness. In the group to which the vitamin was administered continuously even after irradiation, the content of the vitamin was found to be increased in the kidney, liver and small intestine, and FAD was also increased in the kidney and liver in comparison with the irradiated group which had not been administered the vitamin. The results suggested that the phosphorylation of riboflavin was not interfered even with a heavy irradiation when a large amount of the vitamin had been previously given.
日本ビタミン学会の論文
1960-00-00