ネコにおけるビタミンB_<12>の吸収と胃液B_<12>結合たんぱく質の関係

概要

論文の詳細を見る
In view of the recent demonstration of the lack of intrinsic factor activity in dog gastric juice, both B_<12> absorption and the role of gastfic juice were investigated on cats, among carnivorous species. About fifty cats were used in the study, and absorption of ^<57>Co-B_<12> placed in a cleaned and ligated ileal segment was measured. It was found that 0.005-0.03μg of B_<12> was poorly absorbed while absorption of doses above 0.2μg was good. Coadministration of neutralized gastric juice invariably reduced absorption, while dog or human pancreatic juice collected from the duodenum under the influence of Pancreozymin and Secretin increased absorption of small doses of B_<12>. Similar enhancement of absorption of small doses of B_<12> was achieved by rat stomach mucosa extract. The presence of EDTA in the loop, however, did not interfere with the effect of rat intrinsic factor; different absorption mechanism of small amounts of B_<12> in cats was suggested in comparison with species known to have intrinsic factor. These findings in the cat including the B_<12> binders in gastric juice demonstrated by column chromatography and gel-filtration are very similar to those recently reported by Kitazaki in the dog.
日本ビタミン学会の論文
1971-08-25