ビタミンB_1のミクロオートラジオグラム : (II)経口投与時の神経組織のThiamine-^3HおよびO-Benzoylthiamine disulfide-^3Hのとりこみ

概要

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Uptake of thiamine-^3H hydrochloride (B_1-^3H-HCl) and O-benzoylthiamine disulfide-^3H (BTDS-^3H) in both central and peripheral nerve tissues of the mice with oral administration has been studied by microautoradiogram. In the brain and spinal cord two pathways of the vitamin were observed, namely through the capillaries and liquor. In the cerebrum uptake of the vitamin in cortex and basal ganglia was more marked than in white matter. Nerve cells and glia cells exhibited the distinct uptake, though it was more marked in the former. Uptake of the nerve cells was different in degree, according to their histological localization or individual saturation state of the cells. In the cerebellum uptake of B_1-^3H and BTDS-^3H was most marked in Purkinje cells and then in granular layer. In spinal cord nerve cells of each column exhibited marked uptake. In lower neuron, uptake of the vitamin was also distinct in perikaryon, which sent the vitamin into the axon of nervous fibers by axon flow. Thiamine in myelin sheath was supplied by Schwann cells. The motor end-plate revealed more marked uptake than the sensory ending did. In peripheral autonomic neuron the uptake of the vitamin was markedly demonstrated in the perikaryon. In central and peripheral nerve tissues the uptake of BTDS-^3H was more markedly observed than that of B_1-^3H.
日本ビタミン学会の論文
1967-11-25