ビタミンK欠乏の雌性性機能に及ぼす影響にかんする実験的研究 : (II)臓器重量の変動とその組織学的変化

概要

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The adult rats fed on vitamin K free diet were sacrificed in various stage of the experiment and their hypophysis, adrenal, ovary and uterus were weighted and investigated histologically and histochemically. 1) In an early stage of the experiment an apparent weight reduction of hypophysis and uterus was noted and with progress of vitamin K-deficiency the ovarian weight reduction was added. 2) In hypophysis, it was observed the decrease of the acidophilic and basophilic cells in number, contrary to the increase of the chromophobic cells. But when the basophiles are divided into two types of the gonadotrophs and thyrotrophs, the increase of the former is seen throughout the gland and conversely, the latter mostly diminished from the gland. 3) Adrenal cortex was in the state of hyperfunction on the 20th day of vitamin K-deficiency. But about on the 30th day the adrenal cortex was fallen in the state of hypofunction. 4) In ovary, a slight decrease of growing follicles in number was observed on the 20th day of vitamin K-deficiency. 5) In uterus, with the progress of vitamin K deficiency an atrophy in all layers became more obvious gradually.
日本ビタミン学会の論文
1966-01-25