ビタミンB_<12>代謝におよぼす内分泌機能の影響にかんする実験的研究 : (II)下垂体-甲状腺機能のビタミンB_<12>代謝におよぼす影響について

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概要

• 論文の詳細を見る

• The effects of TSH and thyroxin on the metabolism of vitamin B_<12>-^<6〓>Co were studied on male Wistar strain rats. The absorption of orally administered B_<12>-^<6〓>Co was decreased following sither hypophysectomy or thyroidectomy, giving the rates of 47.7±2.8 and 38.4±5.0%, respectively, as compared to 66.4±4.6% in normals. These diminutions could be corrected with TSH or thyroxin, but not with intrinsic factor. In hyperthyroidal state, there was no remarkable difference in the absorption pattern. The fecal excretion of radioactivity following subcutaneous administration of B_<12>-^<6〓>Co increased to 19.3% after thyroidectomy, and decreased to 13.0% after thyroxin administration, when as it was 16.3% in controls. The urinary excretion of radioactivity was correlated with intestinal absorption at oral adminiatration test, and no remarkable hormonal effect could be found after subcutaneous administration test. The hepatic uptake of B_<12>-^<6〓>Co decreased in thyroidectomized state and increased in hyperthyroidal state, but after an excessive administration of thyroxin the hepatic uptake tended to decrease, though no effect was seen upon renal uptake. It could be concluded that the intestinal absorption of vitamin B_<12> was disturbed both in thyroidectomized and in hypophysectomized rats. And further it seems probable that the disturbance of vitamine B_<12> metabolism in hypophysectomized rats may be due to the loss of thyroidal function.

• 日本ビタミン学会の論文
• 1962-12-25

著者

• 上田 進一

  京都大学医学部内科第二講座

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• ビタミンB_代謝におよぼす内分泌機能の影響にかんする実験的研究 : (II)下垂体-甲状腺機能のビタミンB_代謝におよぼす影響について
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