THIOCTIC ACIDの化学的定量法に関する研究 : (IV)尿試料への応用条件の検討ならびにTHIOCTIC ACID負荷後の尿中排泄について

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The previous papers were concerned with a chemical method for thioctic acid determination. In this paper, an applied procedure of the method to rat urine was presented, and the urinary excretion rate of administered thioctic acid was also observed. The results by the method were found to be not affected by the substances in the urine. Namely, a definite amount of thioctic acid added to rat urine was satisfactorily recovered. In normal rats, the total urinary excretion of thioctic acid for 24 hours after administration by various methods was determined by the method. In these studies, similar results were obtained by the chemical method as those by the microbiological method.
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