ビタミンB_1の排泄に関する研究 : とくに腎機能との関係について

概要

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Experiments carried out in toads by the kidney irrigation method showed that thiamine was excreted mainly through the glomeruli. Histochemical investigations made on thiamine distribution in toad kidney tissue revealed that thiamine was secreted and reabsorbed by the tubules. Following the loading of thiamine, the vitamin excreted in urine was determined every 2 ot 3 minutes, and the thiamine loaded was shown to be excreted rapidly in urine. Similar experiments were carried out with cocarboxylase and thiamine propyldisulfide and the results were compared with the ones obtained with thiamine. Thiamine loading (20 mg) and phenolsulfonphthalein tests made simultaneously showed that there was a correlation between the excretions of phenolsulfonphthalein and thiamine. Tests made in rabbits with kidney disturbance developed experimentally with mercuric chloride showed that the excretion of thiamine nearly paralleled that of phenolsulfonphthalein. The excretion of thiamine in urine in relation to kidney function is discussed based on these findings.
日本ビタミン学会の論文