精神疾患のCERULOPLASMIN代謝に関する臨床的研究 : とくに分裂病の血清CERULOPLASMIN値と酵素反応におけるアスコルビン酸との関係について

概要

論文の詳細を見る
The author investigated ceruloplasmin, one of blood enzymes, from the viewpoints of the enzyme activity and the activity as a metabolic factor of the heavy metals in central nervous diseases. At the same time, he observed the close relation with vitamin which was essential in the metabolism in vivo, especially with ascorbic acid which was directly connected with the redox action, and tried to clarify the significance of ascorbic acid in ceruloplasmin metabolism. Among various central nervous diseases, ceruloplasmin oxidase activity increased in the average in schizophrenic group compared with that in normal controls, but such tendency was observed in several other central diseases, and therfore was not specific to schizophrenics. As for ascorbic acid concentration, it decreased in schizophrenic group than in normal controls. Besides, there was correlation between the increase of the activity and the decrease of the concentration, and these were nearly parallel in normal controls too. There were also some other diseases in which the increase of the activity and the decrease of the concentration were observed, but no significant relation was found between them. Furthermore, in relation with these enzyme systems, the influence of hormone on the enzyme activities and the correlation between hormone and ascorbic acid concentrations were investigated.
日本ビタミン学会の論文