THIAMINE PROPYLDISULFIDEとビタミンB_2の関係に関する研究 : (I)TPD経口負荷が健康小児の尿中ビタミンB_2量ならびに健康人工栄養乳児の尿中および血中ビタミンB_2量に及ぼす影響

概要

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No significant increase of urinary riboflavin could not be recognized in the normal children given orally 0.2 mg per kg of body weight of TPD for ten days. In case of oral administration of 0.4 mg per kg of TPD through catheter for 28 days to healthy infant under artificial feeding, the urinary excretion of riboflavin seemed to increase in the first week after the administration, but it tended to decrease in the second week. On the other hand, a trasient decrease of riboflavin was recognized in the blood of bottle-fed infant similarly treated for 21 days. Generally, the administration of TPD caused a temporary increase of FAD in the blood soon after the treatment but a gradual decrease thereafter, and an increase again after three weeks. FMN in the blood was in an inverse relation with FAD against the administration of TPD, while a decrease of free riboflavin was observed soon after the treatment. Neither normal children nor the healthy infants under artificial feeding showed any clinical symptoms of riboflavin deficiency such as glossitis, angular stomatitis, and cheilitis.
日本ビタミン学会の論文