TOXOPYRIMIDINE群物質の研究 : (XXIV)2,5-DIMETHYL-4-AMINOPYRIMIDINEおよび2-METHYL-4-AMINO-5-AMINOMETHYLPYRIMIDINEの肝臓障害作用について

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概要

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• The action of 2,5-dimethyl-4-aminopyrimidine, one of the toxopyrimidine group substances with a structure similar to OMP on the liver was studied by following the weight pattern and histological investigations and it was found that liver function was disturbed by administration of this compound. Differing from OMP, the liver disturbing effect could not be suppressed by vitamin B_6 administration. Histological studies were also conducted on 2-methyl-4-amino-5-aminomethylpyrimidine, a member of the atoxopyrimidine group. It was found this compound, in itself, had a liver disturbing action. The weight curve and histological picture of the liver showed that this compound enhanced the toxicity of OMP.

• 日本ビタミン学会の論文

著者

• 今田 稔

  大阪大学医学部小児科学教室

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• TOXOPYRIMIDINE群物質の研究 : (XXIV)2,5-DIMETHYL-4-AMINOPYRIMIDINEおよび2-METHYL-4-AMINO-5-AMINOMETHYLPYRIMIDINEの肝臓障害作用について

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