TOXOPYRIMIDINE群物質の研究 : (XXIII)2-METHYL-4-HYDROXY-5-HYDROXYMETHYLPYRIMIDINEおよび2-METHYL-4-AMINO-5-AMINOMETHYLPYRIMIDINEの効果の逆転現象について

スポンサーリンク

概要

• 論文の詳細を見る

• It was found that administration of an atoxopyrimidine group substance, 2-methyl-4-hydroxy-5-hydroxymethylpyrimidine in vitamin B_6 deficient mice resulted in an intensification of the OMP induced running fit. The brain metabolism was investigated in an attempt to clarify the cause of this reverse phenomenon and it was found that glutamic decarboxylase is strongly inhibited and γ-aminobutylic acid is reduced. Administration of another substance of the atoxopyrimidine group, 2-methyl-4-amino-5-aminomethylpyrimidine also intensified the running fit by OMP, in this case too, glutamic decarboxylase was strongly inhibited.

• 日本ビタミン学会の論文

著者

• 関 正道

  大阪大学医学部小児科学教室

関連論文

• TOXOPYRIMIDINE 群物質の研究 : (XVIII)HYDROXYLAMINE および THIOSEMICARBAZIDEの疾走痙攣作用について
• 55.トキソピリミジンの研究(II) : 類似物質の毒性試験(第8回大会研究発表要旨)
• 20.2-Methyl-4-hydroxy-5-oxymethylpyrimidineの作用逆転現象について(第9回大会研究発表要旨)
• TOXOPYRIMIDINE群物質の研究 : (XXIII)2-METHYL-4-HYDROXY-5-HYDROXYMETHYLPYRIMIDINEおよび2-METHYL-4-AMINO-5-AMINOMETHYLPYRIMIDINEの効果の逆転現象について
• 急性灰白髄炎患者の脳脊髄液中塩素量について

スポンサーリンク