髄液によるALLITHIAMINEならびにその同族体のビタミンB_1への復帰に関する研究 : (III)ビタミンB_1およびTHIAMINE PROPYL DISULFIDEの髄液への移行について

概要

論文の詳細を見る
Thiamine concentration in the cerebrospinal fluid was measured after intravenous and intramuscular administration of thiamine and thiamine propyl disulfide and the following results were obtained. (1) No difference of thiamine concentration in cerebrospinal fluid of normal children was found between the administration of thiamine and thiamine propyl disulfide. However, with meningitis patients, the concentration of thiamine in the cerebrospinal fluid was slightly higher when thiamine propyl disulfide was administered. (2) When thiamine propyl disulfide was administered intramusculary, the concentration of thiamine in cerebrospinal fluid was higher and maintained longer its level than when it was injected intravenously. (3) For patients in the acute stage of poliomyelitis an administration of thiamine propyl disulfide resulted in higher level of thiamine in the cerebrospinal fluid than an administration of thiamine hydrochloride. However, for patients in the convalescent stage there was no difference in thiamine concentration between thiamine and thiamine propyl disulfide administration.
日本ビタミン学会の論文
1958-00-00