自律神経系刺戟時の臓器ビタミンB_1代謝 : (I)自律神経中枢刺戟時の臓器ビタミンB_1代謝ならびにCHLORPROMAZINEの影響

概要

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The relationship between the autonomic nervous center and stress in thiamine metabolism in the organs were observed. 1) In rabbits the stimulation of sympathetic center in the hypothalamus caused a considerable decrease of total thiamine concentration in the liver (-61%) and kidney (-68%) after one hour and recovery after 24 hours. The cold stimulation caused a decrease of total thiamine in the liver after one hour (-38%) but a considerable decrease after 24 hours (-54%). Likewise the cold stimulation caused a decrease in the kidney after one hour (-27%) but a considerable decrease after 24 hours (-53%). 2) Simultaneous administration of Chlorpromazine suppressed the decrease due to stimulation. 3) Subcutaneous injection of Chlorpromazine did not show any influence in thiamine concentration, except for a slight decrease in the liver and kidney after one hour.
日本ビタミン学会の論文