肝障害時の酸化機転とCOENZYMEA代謝 : (I)肝疾患々者のα-ケト酸代謝とアセチル化能

概要

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The rate of increase in urinary pyruvate and α-keto-glutarate in the first and the second hour following the intravenous administration of 20ml of 20% fructose in comparison with urinary excretion of these acids in 1 hour before fructose administration was measured. In patients with various liver diseases the rate of increase in urinary α-keto-acids was more marked than that in normal subjects. This data suggests that there may be disturbance in the metabolism of a-keto-acids in these patients. The acetylating activity following oral administration of 500mg p-aminobenzoic acid was decreased in patients with various liver diseases than in normal subjects. The decrease of acetylating activity was most marked in those with acute hepatitis.
日本ビタミン学会の論文