DESOXYPYRIDOXINEによる痙攣の研究 : (I)マウスにおけるDESOXYPYRIDOXINE痙攣の実験的研究

概要

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By the injection of 4-desoxypyridoxine, the so called antimetabolite of vitamine B_6,in dosis of 0.15-0.3 mg per gram body weight to mice, it was recognized that 100 out of the 140 rats (71.4%) injected showed characteristic convulsions and 62 rats died. Against this injury, pyridoxine, pyridoxamine and glucuronic acid were found to have some antagonistic action to a narrow extent and this antagonism was by no means such a stabilized one as the case of vitamin B_6 to toxopyrimidine.
日本ビタミン学会の論文