ニコチン酸の代謝に関する臨床的ならびに実験的研究 : (I)ニコチン酸の負荷試験に関する吟味と健康人におけるニコチン酸アミドの負荷試験

概要

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The purpose of this study is to find out a reliable test for detecting the niacin metabolism in man by a parenteral test dose of niacin or nicotinamide. Systematic studies were made on the effect of varying doses and routes of administration upon the blood level of niacin and co-dehyrogenase, and upon the urinary excretion of niacin and N-methylnicotinamide. (1) The blood niacin and co-dehydrogenase levels were not changed by a subcutaneous test dose of nicotinamide ranging from 50 to 500mg. On the other hand, these levels were slightly increased by a test dose of 100 mg niacin in contrast to the equivalent amount of nicotinamide. The use of niacin is, however, not recommendable on account of its side effects. (2) The increase in urinary niacin continued during a 3-hour period following a test dose, while that in urinary N-methylnicotinamide lasetd for 24 hours. Thus, a subcutaneous test dose of 100 mg nicotinamide, together with the determination of the niacin and N-methylnicotinamide excretion in the urine specimen voided for 24 hours following the test dose was found to be a satisfactory method for the study on the niacin metabolism.
日本ビタミン学会の論文