標識リノール酸メチル, 同過酸化物およびその熱分解生成物投与ネズミにおける放射能の体内分布ならびにビタミンE投与の影響(予報)

概要

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Hydroperoxide of methyl linoleate-^<14>C was prepared from linoleic acid-l^<14>C by esterification and autoxidation. After chromatographic purification, the hydroperoxide was decomposed by heating in the inert gas at 100℃. The rats were divided into four groups and were fed with these preparations via stomach tube. Distribution of radioactivity in various organs in the rats was compared in these groups. The distribution of ^<14>C in the rat tissues fed with hydroperoxide resembled to those given the heat decomposition products, but it was quite different from that in the control. The result shows that hydroperoxide may be absorbed as decomposition products into the rat body. The distribution of ^<14>C in the rats fed with the peroxide and vitamin E was almost the same as that in the control. From this result, it is suggested that vitamin E may act as the peroxide decomposing agent, besides as free radical inhibitor, previously known.
1967-03-25