正常人羊膜継代培養細胞(JTC-3細胞)の生育に及ぼすビタミンB_1およびその誘導体の影響 : (I)至適濃度にかんする研究

概要

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JTC-3 cells were grown on a synthetic medium containing thiamine and its various derivatives at different concentration and the activity for cell growth was studied. Thiamine was proved to be essential for the growth of the cells and the latter was able to synthesize carboxylase from thiamine or its derivatives. The optimal concentration for thiamine, TATD, other disulfide-type compounds, excluding TATD, and phosphate-type derivatives were, in terms of thiamine, 0.1,1,0.001 and 0.1μg/ml, respectively. The difference in optimal concentration is considered to be due to the different activity of these compounds, and the difference between TATD and the other disulfide-type thiamine desivatives is supposed to be due the lipoic acid moiety of the former. The potency for cell growth at the optimal concentration of various thiamine derivatives did not show a significant difference.
日本ビタミン学会の論文
1962-02-25