麻酔とくに老人の麻酔とビタミンB_1代謝
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概要
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The present paper describes the thiamine metabolism after anesthesia. After the subcutaneous injection of 20 mg of thiamine, fluctuations of total and bound thiamine were examined in the blood and of urinary thiamine in 3 hours. Simultaneously pyruvic acid in the blood and liver were also determined. As for the ether anesthesia, a slight change was found in the young and middle ages with normal liver function. However, in some persons of old ages with latent abnormality of thiamine metabolism before the operation, free thiamine in blood and 3 hours urine were increased after the operation. As for the nitrous oxide anesthesia, no change of thiamine metabolism was detected after operation even in old age. As for the fluothane anesthesia, disturbance of thiamine utilization was detected under 1 to 2% concentration with 1l/min, oxygen, but it was improved by an increase of oxygen to 4l/min. and employment of the semi-closed circle method before operation. A parallel relation was seen between thamine metabolism and liver function by the BSP test. The BSP test and thiamine metabolism returned to normal about one week after the general anesthesia. But thiamine metabolism in patients with disturbed liver function was very complicated and disturbance remained for a long period in many cases. From the experimental results and referencial consideration, circulated blood amount in the liver should be a great factor of abnormal thiamine metabolism after the general anesthesia. In order to supply a sufficient oxygen, anoxia under anethesia must be avoided, and administration of thiamine diphosphate with ATP or some thiamine derivatives should be recommended.
- 日本ビタミン学会の論文
- 1964-02-25
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関連論文
- 麻酔とくに老人の麻酔とビタミンB_1代謝
- 42.麻酔とビタミン(III) : 肝障害時術後ビタミンB_1代謝およびその対策(第15回日本ビタミン学会大会研究発表要旨)
- 79.麻酔とビタミン(II)(第14回日本ビタミン学会大会研究発表要旨)
- 69.麻酔とビタミン(I) : エーテル麻酔とビタミンB_1(第13回大会研究発表要旨)