門脈圧亢進症患者のピルビン酸代謝ならびにこれに及ぼすビタミンB_1およびコカルボキシラーゼの影響

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概要

• 論文の詳細を見る

• Blood pyruvic acid concentration was determined in 34 portal hypertention cases. The obtained values were higher than those usually found in healthy subjects, and could hardly be lowered by injection of thiamine but injection of cocarboxylase was sometimes effective in reducing them. After a prolonged liver protection treatment, the lowering effect of cocarboxylase became eminent except for 7cases which showed no response to the injection of cocarboxylase. When porta-caval anastomosis was performed, the pyruvic acid values in the blood were elevated remarkably in all cases. In cases with mild elevation it could be decreased by a prolonged supply of thiamine or cocarboxylase, but not in cases with considerable elevation. The cases in which high pyruvic acid levels showed any response neither to injection of thiamine or cocarboxylase, nor to liver protection treatment before the operation proved always of bad prognosis. Supply of cocarboxylase to patients with Eck-fistula syndrome was sometimes effective.

• 日本ビタミン学会の論文

著者

• 小枝 一郎

  名古屋大学医学部第二外科教室

関連論文

• 85.門脈圧亢進症患者のピルビン酸代謝およびこれに及ぼすビタミンB_1,コカルボキシラーゼの影響(第9回大会研究発表要旨)
• 門脈圧亢進症患者のピルビン酸代謝ならびにこれに及ぼすビタミンB_1およびコカルボキシラーゼの影響

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