クル病における血清アルカリフォスファターゼの意義に関する研究 : (VI)ビタミンD投与と燐酸治癒との差について : (2)血清および臓器アルカリフォスファターゼ

概要

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Following the previous report, the alkaline phospatase activities of serum and of several organs in rats were studied in "phosphate cure" and in "vitamin D cure" of rickets. The conclusions were as follows : (1) The alkaline phosphatase activity of small intestine had primarily no effect on the absorption of phosphate. (2) In phosphate cure, the alkaline phosphatase activity of bone was very low compared with in vitamin D cure. Such variations in bone were possible due to the amount of osteoblasts appearing in primordial bone marrow. (3) Vitamin D activated the alkaline phostphatase of organs, especially intracellular one, and its activating effect reached to the maximum at 48 or 72 hours after the administration of vitamin D. (4) It is assumed that the variation of the activity of intracellular alkaline phosphatase has no influence on the level of the activity in serum.
日本ビタミン学会の論文