四塩化炭素肝障害シロネズミにおけるTetrahydrofolic acidの効果

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概要

• 論文の詳細を見る

• Severe hepatic damage was induced by CCl_4 inhalation in rats treated with phenobarbital. The curative effects of tetrahydrofolic acid (THFA) vs. folic acid (FA) were examined with hematological picture, urinary excretion of formiminoglutamic acid (FIGLU), liver histology and dihydrofolic acid (DHFA) reductase activity as indicators. CCl_4-inhalation resulted in the increase of neutrocyte and the decrease of lymphocyte. The activity of hepatic DHFA reductase was greatly reduced with the increase of urinary output of FIGLU. Urinary excretion of FIGLU returned to normal on treatment with THFA 5 mg/kg s. c. but not with FA.

• 日本ビタミン学会の論文
• 1973-06-25

著者

• 塩崎 哲也

  山之内製薬株式会社中央研究所

関連論文

• Cyclocarbothiamineの研究 : (II)Cyclocarbothiamineの吸収機構および生体内分布について
• Cyclocarbothiamineの臨床 : (I)Cyclocarbothiamineの吸収と排泄
• 四塩化炭素肝障害シロネズミにおけるTetrahydrofolic acidの効果
• 96.Cyclocarbothiamineの吸収と排泄(一般研究発表要旨)

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