未熟児のビタミンE経口投与時における血漿および赤血球ビタミンEの変動

概要

論文の詳細を見る
Alpha-tocopheryl acetate of 50 mg/kg/day was orally administered every day to low birth weight infants 7 days after birth, and changes in plasma and RBC tocopherol levels were examined. 1. An increase in plasma and RBC tocopherol levels was observed during the first 2 to 3 weeks of the administration which was followed by a slightly decrease thereafter. Changes in plasma tocopherol/total lipid ratio showed a similar pat-tern to those in plasma and RBC tocopehrol levels. 2. During the late periods of examination (more than 2 weeks), plasma tocopherol and tocopherol/total lipid ratio were kept at the levels corresponding to adult values, or higher levels. 3. A close correlation between plasma tocopherol and RBC tocopherol levels was observed all through the periods of administration. 4. A close correlation between plasma tocopherol and plasma total lipids or betalipoproteins was also observed either in the early periods or late periods of the administration. However, the increasement of plasma tocopherol against that of plasma lipids was much larger in the late periods than in the early periods.
日本ビタミン学会の論文
1985-10-25