ビタミンE立体異性体の生物活性と生体内輸送

概要

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Recent studies have shown that due to the presence of α-tocopherol transfer protein (α-TTP) in liver, there is a mechanism that preferentially takes up and uses RRR-α-tocopherol (post-hepatic pathway). However, several reports suggest that the liver is not the only determinant tissue in the utilization of vitamin E. Progress in analytical methods has recently stimulated studies on the chirality of vitamin E. It has been shown that there is no biodiscrimination in the transfer of orally administered vitamin E stereoisomers until the chylomicron stage. The fate of vitamin E stereoisomers within the smaller fragments resnlting from hydrolysis in the blood of the chylomicrons by lipoprotein lipases, is unknown (pre-hepatic pathway). Concerning the pre-hepatic pathway, and in particular how vitamin E incorporated in lipoproteins is taken up by a peripheral tissue where no α-TTP is expressed, an in vitro experimental model was investigated. Results suggested that skeletal muscle myoblasts do not discriminate vitamin E stereoisomers.
日本ビタミン学会の論文
2000-07-25