シロネズミ肝におけるパントテン酸, Coenzyme Aおよびその中間体の分布にかんする研究 : (II) 種々量のパントテン酸投与時の肝CoAおよびその中間体の分布, ならびに4'-Phosphopantothenoylcysteine decarboxylase活性

概要

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By giving pantothenic acid deficient diet or large amount of pantothenic acid, the distribution of pantothenic acid, CoA and their intermediates in rat liver was observed. The result of this study obtained from the composition technique of CoA to phosphopantetheine by phosphatase was quite similar to our previous result derived from the biosynthetic method of CoA from phosphopantetheine or dephospho-CoA by dephospho-CoA pyrophosphorylase and dephospho-CoA kinase. Phosphopantetheine and dephospho-CoA contents in rat liver decreased by giving pantothenic acid deficient diet and the amount of phosphopantothenic acid and phosphopantothenoylcysteine increased by giving large amount of pantothenic acid. Therefore, CoA level was usually kept constant under above-mentioned two conditions. The activity of phosphopantothenoylcysteine decarboxylase was compaired under these different situations, but no significant difference was found.
日本ビタミン学会の論文
1969-11-25