正常宿主で認められたサイトメガロウイルス感染症による多発性胃潰瘍の一例

概要

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Cytomegalovirus (CMV) is recognized an important pathogen of severe infections in immunocompromised hosts, and causes CMV mononucleosis with multi-organ involvements. Although CMV infections in the gasrointestinal tract of immunocompromised hosts have been reported, there have been only a few cases of CMV inclusions in the gasrointestinal ulcers in normal hosts. Here a case of normal nonimmunocompromised host is discribed; the patient was 43 years old male complaining abdominal pain, vomitting, and fever with mononucleosis and hepatitis, and had revealed multiple gastric ulcers in upper gastrointestinal endoscopy. Although histologic examination of biopsies from excisional stomach did not demonstrate cytomegalovirus inclution bodies, both IgM and IgG antibody to CMV were positive. However, the patient had no detectable immunological abnormalities, history of blood transfusion or organ transplant, and the use of immunosuppressants. Conventional antiulcer treatments were not effective, whereas the patient was naturally cured without the administration of anti-viral agents. In conclusion, CMV mononucleosis can be associated with multiple gastic ulcers in this case. CMV is thought to be a cause of gastric ulcer in the normal non-immunocompromised host.
山口大学医学会の論文
2000-06-30