實驗的動脈硬化症の研究(第1報) : Cholesterol飼養家鶏に於けるHypercholesterolemia時のCholesterol Transport Mechanismに就いて
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The changes of cholesterol transport mechanism in hypercholesterolemia of cholesterol-fed chicks were examined by means of starch electrophoresis.The mean value of serum total cholesterol in chicks (RO group) receiving normal mash diet supplemented by 5 per cent cottonseed oil was 83 mg per cent. Cholesterol content in albumin and α_1-globulin, α_2-globulin, β-I, β-II, β-III and γ-globulin was 47 mg%, 8 mg%, 3.5mg%, 3.6 mg%, 16 mg% and 5 mg%, respectively. In other words, cholesterol content was highest in albumin and α_1-globulin.In COI group, the serum total cholesterol was 281 mg per cent. Cholesterol content in albumin and α_1-globulin, α_2-globulin, β-I, β-II, β-III globulin and γ-globulin was 62 mg%, 20 mg%, 56 mg%, 82 mg%, 51 mg% and 12 mg%, respectively. Cholesterol increased in each protein fraction, but the degree of increase was not similar. It increased more markedly in β-I and β-II of β-globulin.In COII group, the serum total cholesterol was 1158 mg per cent. Cholesterol centent in albumin and α_1-globulin, α_2-globulin, β-I, β-II, β-III and γ-globulin was 113 mg%, 301 mg%, 383mg%, 366 mg%, 38 mg% and 16 mg% respectively. Cholesterol increased markedly and was highest in α_2-globulin, β-I and β-II.While the β-lipoprotein/α-lipoprotein ratio which was determined by paper electrophoresis was 4.6 in RO group, the β-lipoprotein cholesterol/α-lipoprotein cholesterol ratio was 0.50. In COI proup, the β-lipoprotein/α-lipoprotein ratio and β-lipoprotein ratio and β-lipoprotein cholesterol/α-lipoprotein cholesterol ratio were 21.7 and 21.6 respectively.
- 社団法人日本循環器学会の論文
- 1959-08-20
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関連論文
- 実験的動脈硬化症の研究(第2報) : Estrogen投與によるCholesterol飼養家鶏の腦内小動脈, 腎内小動脈及び冠動脈の動脈硬化性病變の抑制について
- 實驗的動脈硬化症の研究(第1報) : Cholesterol飼養家鶏に於けるHypercholesterolemia時のCholesterol Transport Mechanismに就いて