實驗的動脈硬化症における動脈壁の酵素學的研究 : GO-T活性について
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1) The normal mean valve of aortic GO-T activity, which was determined by the present author for the first. Time in the world, was approximately 4,300 Tonhazy unit in 44 examined rabbits, being equivalent to I/40 of hepatic activity meanwhile determined. The normal range of aortic GO-T activity was smaller in comparison with that of the hepatic and serum GO-T, as to suggest the possibility that the arterial tissue might be "Protein Stable".2) In lanolin-fed rabbits (L), marked rise and fall were noted in aortic GO-T activity in the cource of atherma formation. The abrupt depression in the enzymatic activity prior to the macroscopic atheroma development was particularly of interest.3) The development of atheromatous plague were found accelerated by both castration and androgen administration (CL and ACL), in case of the latter (ACL), depressin in aortic GO-T activity was extremely dramatic. Effects were hardly noticed on the occasion of estrogen administration (EC and ECL), neither enzymologically nor morphologically.4) Elevation in aortic and hepatic GO-T astivities were induced by thyroxin administration (T) and, contrarily, depression of the both was noticed when lipide administration was combined together (TL). Another "Pre-artheromatous" edpression in aortic GO-T activity was encountered on the occasion of thiourcil administration (M vs. ML), where atheramatous lesions developed, too.5) It was shown that the changes in aortic GO-T activity were peculiarly different from the hepatic and serum activities either when lanolin, estrogen, androgen or thiourcil was administered but thyroxin. The attitudes, hepatic and serum GO-T activities took, seemed always opposite each other. On the other hand, the degree of hypercholesteremia and/or of increase in L. I. were shown not always parallel to that of atheromatous lesions.6) From the fact that a definite tendency was noted upon the changes in aortic GO-T activity during atheroma formation, which have been observed on these series of in vitro experiment, it is suggested that glutamic acid metabolism of the aortic tissue may play an important role on genesis of atherosclerosis.
- 社団法人日本循環器学会の論文
- 1959-10-20
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- 實驗的動脈硬化症における動脈壁の酵素學的研究 : GO-T活性について