副腎靜脈カテーテル法による副腎カテコールアミン排出に關する研究 : 各種ストレス及び二・三藥劑の影響について
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概要
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Adrenal secretion and cardiac uptake of catechol amine (C.A.) were studied on 32 dogs anesthetized with amobarbital and 4 dogs with morphine-chloralose, to clarify the role of C.A. played at the time of various stresses, especially on the heart. In addition, the effect of some agents on C.A. secretion was investigated.Adrenal vein catheterization without laparotomy was performed to collect adrenal venous blood. Weil-Malherbe & Bone's methods were used to determine C.A. concentration of plasma.Thus, following results were obtained on amobarbital anesthetized dogs : I. C. A. concentrations of adrenal venous plasma collected by this technique were much lower than those of plasma collected after laparotomy.II. Remarkable increase of C.A. concentration in adrenal venous plasma was observed transiently in following conditions. (a) After cervical vagotomy and sympathectomy. (b) At the time of hemorrhagic shock. (c) 1. After coronary embolization. 2. During and/or after the transient occlusion of the left coronary artery. (The increase in both conditions was delayed or could not be found after sympathectomy, whereas it was not affected by vagotomy.) (d) After intravenous administration of Theraptique or acethyl choline.III. During adrenaline or noradrenaline infusion after hemorrhagic shock, C.A. was taken up by the heart muscle at the time when the blood pressure was elevating, and was released from it, when the blood pressure reached a constant level.From these facts, the author concluded that the impulse from the heart was transmitted to the adrenal glands via sympathetic nerve, resulting in the increased secretion of C.A., a part of which was taken by the heart muscle, and that the increase of C.A. secretion was, therefore, not only a mechanism to overcome various stresses, but also regulated cardiac performance.
- 社団法人日本循環器学会の論文
- 1959-09-20