動脈硬化症に関する研究-内因性脂質清淨能について
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概要
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As there is a lack of agreement concerning the role of the heparin-clearing factor system in the pathogenesis of atherosclerosis, a method was presented for the determination of endogenous clearing activity. Then the endogenous clearing activity was investigated with respect to serum lipid levels, function of various endocrine organs and various diseases.The following results could be obtained : 1) Endogenous clearing activity was not related with serum levels of total fatty acid, neutral fat, phospholipid, nonesterified fatty acid and total lipid.In cases with high serum cholesterol levels and high atherogenic index, the endogenous clearing activity was below normal.There was an inverse correlation between the endogenous clearing activity and cholesterol/phopholipid ratio.2) Endogenous clearing activity decreased with age.3) In hypertension cases, the endogenous clearing activity became lower as the distolic pressure increased and the inhibition of clearing activity was stronger in hypertensive subject with pathological findings in eye grounds than in those with normal eye grounds.4) As for endogenous clearing activity and plasma protein-bound iodine level, no significant relationship was found between them.5) Cases with high levels of plasma 17-OH-corticosterone gave lower values for endogenous clearing activity, and the adminstration of ACTH, cortisone, prednisolone and lipomobilizing factor resulted in its marked decrease.6) Lower values for endogenous clearing activity than any obtained in the controls were noted in patients with diabetes mellitus, angina pectoris, myocardial infarction cerebro vasucular lesion and hypertension.Endogenous clearing activity was slightly highes in cases with liver cirrhosis than normal subjects.The sesults obtained support the view that the heparin-clearing factor system has an inportant role in disturbing the lipid metabolism in cases of atherosclerosis.
- 社団法人日本循環器学会の論文
- 1959-09-20