清淨因子を中心とした動脈硬化症の研究
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Recently disturbance in lipid metabolism has become an important problem for the study of arteriosclerosis, the excessive lipid in blood being considered both experimentally and clinically as a cause of this disease. Since Hahn found that heparin cleared alimentary lipemia in the body, many studies have been made on the behavior and nature of an active serum substance ("Clearing factor" by Korn et al.), which is produced by the intravenous injection of heparin. With the advance of analytical techniques such as ultracentrifugation and paper-electrophoresis, a new idea has been introduced concerning blood lipid, and the clearing factor is now considered closely related with lipemia and the restoration of the normal lipoprotein. Since the quantitative determination of the endogenous clearing factor is difficult at present, experimental studies were carried out on the post-heparin serum clearing factor and on its relationship to atherosclerosis.1) Serum factor required for the production of the clearing factor was contained in a large amount in α-globulin.2) A large proportion of the clearing factor in the serum, formed after the intravenous injection of heparin, tended to be contained in serum albumin fraction.3) Between the clearing factor and antithrombin II, which both are increased after the in-_travenous injection of heparin, there were evident differences in the time of appearance after heparin injection, the behavior against inhibitors, the thermostability, and the distribution in serum protein fraction.4) The formation of the clearing factor by heparin was investigated with various human organs removed at autopsy, and the formation was found increased in the order : The aorta, kidney, liver, spleen, pylorus, heart, lung, and pancreas. No organ specificity was found for the clearing-factor-forming ability. This ability was found decreased in tissues with marked arteriosclerosis.5) The ability declined with advance in age, more remarkably in the male. In the female no such decline was observed before the age of 40 years. When age and diseases were disregarded, mean value of the clearing factor was rather higher in man than in woman.6) The ability was lower in hypertensive group than in the normal.7) When the normal and abnormal electrocardiographic groups were compared, the ability was lower in the latter, which presented abnormal RS-T segments. 8) The ability was lower in cases with high atherogenic index than in the normal.9) When various diseases were compared, the ability was remarkably decreased in angina pectoris, myocardial infarction, diabetes mellitus, cardiac asthma, and hypothyrodism.
- 社団法人日本循環器学会の論文
- 1958-12-20
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関連論文
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- 清淨因子を中心とした動脈硬化症の研究