23aC1 機能性物質の晶析とスケールアップ(バイオI)
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概要
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Control of particle size and particle size distribution in batch crystallization, are very important to improve the product quality. Product quality affect the solubility and pharmaceutical fomulation process, eg. Particle flowability, tablet compressibility, powder filling. The following are successful examples to control the physical properties in large scale. The simple scale up method for batch crystallization is described. This method is based on Z factor which corresponds to minimum agitation speed for suspension. It can control the particle size, particle size distribution and reaction rate for scale up.
- 日本結晶成長学会の論文
- 1999-07-01
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- 23aC1 機能性物質の晶析とスケールアップ(バイオI)