<Originals>Sarcoplasmic Reticulum Function of Rat Diaphragm Following Five-day Inactivity

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MIYATA, H. and WADA, M., Sarcoplasmic Reticulum Function of Rat Diaphragm Following Five-day Inactivity. Adv. Exerc. Sports Physiol., Vol.7, No.1 pp27-32, 2001. We hyporthesize that the adaptation of sarcoplasmic reticulum (SR) function in muscle fiber to inactivity is affected not only by muscle activity itself but also by some trophic factors. We compared two hemidiaphragm models in rats; 1) Spinal cord hemisection (SPH) at cervial second level; ") Denercation (DNV) in phrenic nerve. After 5 days, contraction time (CT) and half relaxation time (1/2RT), and SR Ca2+-ATPase activity were measured. There were no significant changes in CT and 1/2RT in the SPH, but significant alterations in the DNV. As compared to the control (CTL) group. SR Ca2+-ATPase activity decreased in the DNV but was unchanged in the SPH group. No differnces in the population and cross-sectional area of each muscle fiber type were found among the SPH. DNV and CTL groups. Our results suggest that the rapid adaptations of SR function to inactivity were not attributable to the changes in muscle fiber types, and that some neurotrophic factors from phrenic motoneurons influence the adaptation.
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