Molecular Mechanisms Involved in Determination of Muscle Fibre Mass and Phenotype.
スポンサーリンク
概要
- 論文の詳細を見る
G. GOLDSPINK, Moiecular Mechanisms invoived in the Determination of Muscle Fibre Mass and Phemthype. Abv. Exerc. Sports Physiol., Vol.5, No.2 pp.27-39, 1999. Skekectal muscle is one of the best exaples of a tissue that can adapt by qualitatively and quantiatively changing gene expression in response to functional demands. The genes include the members of myosin heavy chain (he) family which are involved not only in muscle mass regulation but are the main determinants fo muscle fibre phenotype as they encode us to identify which myosin genes are wxpressed in single fibres during growth and during exercise. This has shown that the main fast fibre types in human are 2x nad 2a and not 2b as in rat muscle. In order to understand the regulation of the indivisual ecnes we have studied their 5' and 3' flanking soquences and used their promter sequences to engincered genes to inject them back into muscle for bene therapy purpose as well as to study regulation. However, in order to after gene expression, mechanical signals have to transduced into chemical signals. Our group have cloned toe cDNA of two splice wariants of the insulin like growth factor(IGF-1) gene that are produced by active muscle. These inclide a liver or endocrine type (L,IGF-a) and another we call mechano growth factor (MGF) that appears to have a local or sutocrine/paracrine function. Although the liver is usually thougt of as source of circulating IGF-1, it has recently been shown that during exercise, skeletal muscle produces much of the circulating IGF-1. Therefore these growth factors appear to be involved in both local repair and maintenance of muscke mass and leads to adaptive remodeling.
- 日本運動生理学会の論文
著者
関連論文
- Fish as Bioreactors : Transgene Expression of Human Coagulation Factor VII in Fish Embryos
- Molecular Mechanisms Involved in Determination of Muscle Fibre Mass and Phenotype.