Extreme Catalysts from Low-Temperature Environments
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概要
- 論文の詳細を見る
Cold-loving or psychrophilic organisms are widely distributed in nature as a large part of the earth's surface is at temperatures around 0℃. To maintain metabolic rates and to prosper in cold environments, these extremophilic organisms have developed a vast array of adaptations. One main adaptive strategy developed in order to cope with the reduction of chemical reaction rates induced by low temperatures is the synthesis of cold-adapted or psychrophilic enzymes. These enzymes are characterized by a high catalytic activity at low temperatures associated with a low thermal stability. A study of protein adaptation strategies suggests that the high activity of psychrophilic enzymes could be achieved by the destabilization of the active site, allowing the catalytic center to be more flexible at low temperatures, whereas other protein regions may be destabilized or as rigid as their mesophilic counterparts. Due to these particular properties, psychrophilic enzymes offer a high potential not only for fundamental research but also for biotechnological applications.
- 2004-11-25
著者
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Blaise Vinciane
Laboratory Of Biochemistry Institute Of Chemistry B6 University Of Liege
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HOYOUX ANNE
Laboratory of Biochemistry, Institute of Chemistry B6, University of Liege
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COLLINS TONY
Laboratory of Biochemistry, Institute of Chemistry B6, University of Liege
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GRATIA EMMANELLE
Laboratory of Biochemistry, Institute of Chemistry B6, University of Liege
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HUSTON ADRIENNE
Laboratory of Biochemistry, Institute of Chemistry B6, University of Liege
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MARX JEAN-CLAUDE
Laboratory of Biochemistry, Institute of Chemistry B6, University of Liege
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SONAN GUILLAUME
Laboratory of Biochemistry, Institute of Chemistry B6, University of Liege
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ZENG YINXIN
Laboratory of Biochemistry, Institute of Chemistry B6, University of Liege
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FELLER GEORGES
Laboratory of Biochemistry, Institute of Chemistry B6, University of Liege
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GERDAY CHARLES
Laboratory of Biochemistry, Institute of Chemistry B6, University of Liege
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Zeng Yinxin
Laboratory Of Biochemistry Institute Of Chemistry B6 University Of Liege
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Hoyoux Anne
Laboratory Of Biochemistry Institute Of Chemistry B6 University Of Liege
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Collins Tony
Laboratory Of Biochemistry Institute Of Chemistry B6 University Of Liege
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Gerday Charles
Laboratory Of Biochemistry Institute Of Chemistry B6 University Of Liege
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Feller Georges
Laboratory Of Biochemistry Institute Of Chemistry B6 University Of Liege
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Huston Adrienne
Laboratory Of Biochemistry Institute Of Chemistry B6 University Of Liege
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Sonan Guillaume
Laboratory Of Biochemistry Institute Of Chemistry B6 University Of Liege
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Marx Jean-claude
Laboratory Of Biochemistry Institute Of Chemistry B6 University Of Liege
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Gratia Emmanelle
Laboratory Of Biochemistry Institute Of Chemistry B6 University Of Liege
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D'amico Salvino
Laboratory Of Biochemistry Institute Of Chemistry B6 University Of Liege