Soluble Intercellular Adhesion Molecule-1 and Vascular Cell Adhesion Molecule-1 Concentrations, and Leukocyte Count in Smokers

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The leukocyte count and concentrations of sICAM-1 and sVCAM-1 in smokers were investigated. The subjects were 96 persons (31 smokers and 65 nonsmokers) hospitalized for a complete health checkup examination. There were no differences between the two groups for background factors (age (nonsmokers, 56.2±9.2 vs smokers, 52.6±11.3) gender ratio (m/f) (nonsmokers, 47/18 vs smokers, 24/7) and drinker ratio (+/-) (nonsmokers, 45/20 vs smokers, 26/5)). For smokers, the average number of cigarettes smoked daily, smoking period (ys) and Brinkman Index were 21.4±10.4, 26.2±14.5 and 584.2±476.9, respectively. In smokers, total leukocyte count (/μI) (6371.0±1303.4 vs 5063.1±1279.1, p<0.0001), and sICAM-1 concentration (ng/ml) (202.6±64.0 vs 163.0±60.8, p<0.01) were higher than those in nonsmokers. No significant difference in the sVCAM-1 concentration was shown between the two groups. Items showing large correlation coefficients with the number of cigarettes smoked daily were the total leukocyte count (r=0.45, p<0.0001) and sICAM-1 (r=0.36, p<0.0001). In smokers, sICAM-1 showed correlation with the total leukocyte count (r=0.42, p<0.05). We conclude that the leukocyte count and sICAM-1 concentration in healthy smokers are higher than those in nonsmokers.
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