cGMP-Phosphodiesterase Activity Is Up-regulated in Response to Pressure Overload of Rat Ventricles(Biochemistry & Molecular Biology)
スポンサーリンク
概要
- 論文の詳細を見る
Although expression of natriuretic peptides in cardiac tissues is up-regulated in response to pressure overload, no significant change in cGMP level in hypertrophied ventricles was observed. Activities of two cyclic nucleotide phosphodiesterase (PDE) isoforms, Ca^<2+>/calmodulin-stimulated PDE (PDE1) and cGMP-stimulated PDE (PDE2), were significantly higher in rat left ventricles 14 days after aortic banding. The absence of significant changes in PDE1A and PDE2A mRNA levels indicated that the two PDE activities were post-transcriptionally up-regulated. These results suggested that the increased cGMP-PDE activity in response to pressure overload plays an important role in neutralizing cGMP action in cardiac tissue.
- 2003-05-23
著者
-
Omori Kenji
Discovery Research Laboratory Tanabe Seiyaku Co. Ltd.
-
YANAKA Noriyuki
Discovery Research Laboratory, Tanabe Seiyaku Co., Ltd.
-
KUROSAWA Yukie
Discovery Research Laboratory, Tanabe Seiyaku Co., Ltd.
-
MINAMI Kouichi
Discovery Research Laboratory, Tanabe Seiyaku Co., Ltd.
-
KAWAI Eri
Discovery Research Laboratory, Tanabe Seiyaku Co., Ltd.
-
Kawai Eri
Discovery Research Laboratory Tanabe Seiyaku Co. Ltd.
-
Minami Kouichi
Discovery Research Laboratory Tanabe Seiyaku Co. Ltd.
-
Kurosawa Yukie
Discovery Research Laboratory Tanabe Seiyaku Co. Ltd.
関連論文
- cGMP-Phosphodiesterase Activity Is Up-regulated in Response to Pressure Overload of Rat Ventricles(Biochemistry & Molecular Biology)
- TMC-66, a New Endothelin Converting Enzyme Inhibitor Produced by Streptomyces sp. A5008
- TMC-49A, a Novel Transcriptional Up-Regulator of Low Density Lipoprotein Receptor, Produced by Streptomyces sp. AS1345
- Trichostain A and Herboxidiene Up-regulate the Gene Expression of Low Density Lipoprotein Receptor
- Crystal Structures of Diastereomeric 1 : 1 Complexes of (R)- and (S)-Phenylalanine (S)-Mandelic Acid
- Role of Repetitive Nine-Residue Sequence Motifs in Secretion, Enzymatic Activity, and Protein Conformation of a Family I.3 Lipase
- Isolation and Analysis of Lipase-Overproducing Mutants of Serratia marcescens
- Gram-Negative Bacterial ATP-Binding Cassette Protein Exporter Family and Diverse Secretory Proteins
- Portective Action of Angiotensin Converting Enzyme Inhibitors on Cardiac Hypertrophy in the Aortic-Banded Rat.