Method for Identification of Mutant Glutathione S-Transferases Conferring Enhanced Resistance to the Anti-Cancer Drug Chlorambucil

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概要

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• We screened library of mutant glutathione S-transferases (GSTs) in Escherichia coli by successive treatments with anti-cancer drug chiorambucil and identified mutant GSTs that conferred enhanced resistance to host against chiorambucil compared with wild-type GST. This study provides a method to develop enzymes with improved efficiency of detoxification against cytotoxic substances.

• 公益社団法人日本生物工学会の論文
• 2002-06-20

著者

• Hanyu Yoshiro

  Molecular And Cell Biology National Institute Of Advanced Industrial Science And Technology (aist)

• Hirota Kiyonori

  Molecular And Cell Biology National Institute Of Advanced Industrial Science And Technology (aist)

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• Method for Identification of Mutant Glutathione S-Transferases Conferring Enhanced Resistance to the Anti-Cancer Drug Chlorambucil

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