Enantioselective Esterfication of Racemic Ibuprofen in Isooctane by Immobilized Lipase on Cellulose Acetate-Titanium Iso-Propoxide Gel Fiber
スポンサーリンク
概要
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Lipase (Candida rugosa) was entrap-immobilized on cellulose acetate-titanium iso-propoxide gel fiber by the sol-gel method. The immobilized lipase was used for the direct synthesis of (S)-ibuprofen ester from racemic ibuprofen using propyl alcohol as an acyl acceptor in isooctane. The activity of the immobilized lipase was decreased to about 10-20% that of native lipase. However, the reaction was more enantioselective compared to that with native lipase. The stability for repeated use was improved by immobilization.
- 公益社団法人日本生物工学会の論文
- 2002-01-25
著者
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Ikeda Yuko
Department Of Anesthesiology Osaka City University Graduate School Of Medicine
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Ikeda Yuko
Department Of Materials Chemistry Graduate School Of Engineering Tohoku University
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Kurokawa Youichi
Department Of Materials Chemistry Graduate School Of Engineering Tohoku University
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Kurokawa Youichi
Departent Of Materials Chemistry Graduate School Of Engineering Tohoku University
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