Enhanced Synthesis of Trisporic Acid and β-Carotene Production in Blakeslea trispora by Addition of a Non-Ionic Surgactant, Span 20

概要

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When a non-ionic surfactant, Span 20,was added to a mated culture of Blakeslea trispora, β-carotene production increased 15 fold compared to that without the surfactant, reaching 2.3g/l. The marked increased of β-carotene was closely realted to the titer of trisporic acid, a strong stimulator of β-carotene synthesis. With Span 20,the microorganism produced 15 times more trisporic acid (8.8 mg/g dry cell weight) than without the surfactant (0.6 mg/g dry cell weight) Therefore, it was concluded that Span 20 considerably enhanced the production of trisporic acid, which subsequently stimulated β-carotene synthesis.
社団法人日本生物工学会の論文
1997-10-25