Screening and Mutational Improvement of a D-Ribose Secreting Candida pelliculosa Strain
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概要
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The application of D-ribose in chemistry and pharmacy lately has received much attention. In order to develop an efficient D-ribose production process, a screening strategy was established to isolate naturally occurring D-ribose secreting microorganisms. Of the more than two thousand strains isolated, only four excreted D-ribose in a range from 0.04 to 0.36 g/l, starting from 30 g/l of D-glucose. One strain, identified as Candida pelliculosa, quantitatively co-produced D-arabitol (up to 7 g/l). This strain was subsequently submitted to UV-mutagenesis and a selective nystatin-based enrichment, leading to the isolation of a D-arabitol non-secreting mutant (C. pelliculosa PDW 43 ARA^-), which synthesized 5 g/l of D-ribose from 30 g/l of D-glucose.
- 公益社団法人日本生物工学会の論文
- 1996-07-25
著者
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Soetaert Wim
Laboratory Of Industrial Microbiology And Biocatalysis Faculty Of Agricultural And Applied Biologica
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DE WULF
Laboratory of Industrial Microbiology and Biocatalysis, Faculty of Agricultural and Applied Biologic
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JEROME VANDAMME
Laboratory of Industrial Microbiology and Biocatalysis, Faculty of Agricultural and Applied Biologic
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Jerome Vandamme
Laboratory Of Industrial Microbiology And Biocatalysis Faculty Of Agricultural And Applied Biologica
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De Wulf
Laboratory Of Industrial Microbiology And Biocatalysis Faculty Of Agricultural And Applied Biologica