Characterization and Modeling of Oxygen Transfer in a 20-l Modified Cell-Lift Bioreactor with a Double-Screen Cage

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概要

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• The effects of temperature, agitation speed, aeration rate and the configuration of the cage screen on the volumetric oxygen transfer coefficient (K_La) were investigated in a 20-l modified cell-lift bioreactor with a double-screen cage (CellCul-20A). The results showed that the K_La value increased significantly with an increase of aeration rate. Based on the experimental data, where possible the K_La value was correlated with each operating variable (e.g., the aeration rate). For a better characterization of the oxygen transfer process in the bioreactor, first, the liquid exchange rate across the screen of the cage (Q_s), which was evaluated by an in-house-developed electrolyte pulse technique, was successfully correlated with the agitation speed and aeration rate as follows : Q_S=3.42×10^<-5> N^<1.49>+1.46×10^<-4> U_G^<0.68> (for a double screen) and Q_S=1.93×10-<-5> N^<1.81>+1.13×10^<-4> U_G^<0.61> (for a single screen). The following mathematical model for the oxygen transfewr in deep aeration was then developed : 1/[K_La)_d・V_c]=1/Q_S+1/{V_b・[(K_La)_b-(K_La)_d]}. Using this model, the value of the volumetric oxygen transfer coefficient inside the cage was obtained, and the mass transfer resistances for the bubbling inside the cage and the transfer of liquid across the screen of the cage were compared. The results provide an insight towards a better understanding of the mass transfer mechanisms in the bioreactor.

• 社団法人日本生物工学会の論文
• 1995-07-25

著者

• Yu Jun-tang

  East China University Of Science And Technology Research Institute Of Biochemical Engineering

• WANG SI-JING

  East China University of Science and Technology, Research Institute of Biochemical Engineering

• ZHONG JIAN-JIANG

  East China University of Science and Technology Research Institute of Biochemical Engineering

• CHEN YIN-LIANG

  East China University of Science and Technology, Research Institute of Biochemical Engineering

• Chen Yin-liang

  East China University Of Science And Technology Research Institute Of Biochemical Engineering:(prese

• Wang Si-jing

  East China Univ. Of Sci. & Tech.

• Wang Si-jing

  East China University Of Science And Technology Research Institute Of Biochemical Engineering

• Zhong Jian-jiang

  East China Univ. Of Sci. & Tech.

関連論文

• Characterization and Modeling of Oxygen Transfer in a 20-l Modified Cell-Lift Bioreactor with a Double-Screen Cage
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