Penicillin Productin in an Inverse Fluidized Bed Bioreactor

概要

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The inverse fluidized bed bioreactor was adapted for the axenic culture of heterotrophic microorganisms. Penicillin V synthesized by Penicillium chrysogenum ATCC 28089 was used as a model system for secondary metabolite production. The biomass growth rate was controlled by the rate of nutrient addition while an eroder in the inner draft tube limited the maximum biofilm thickness. When a lactose-rich, mineral salts medium was added at a rate of 0.024 l・h^<-1>, the maximum specific productivity was 5.79×10^<-4> g (Pen V)・g (biomass)^<-1>・h^<-1>.
公益社団法人日本生物工学会の論文
1991-12-25