Fermentative Production of Dipicolinic Acid by Penicillium citreoviride from Sugarcane Molasses

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概要

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• In Penicillium citreoviride strain 3114,dipicolinic acid(DPA)synthesis is inhibited by Ca^<++> ions and susceptible to catabolite repression, making it unsuitable for fermentation in sugarcane molasses. A mutant, 27133-dpa-Ca-14,was derived through stepwise mutation and selection to produce DPA in the presence of 1000 ppm Ca^<++> and also to be resistant to catabolite repression. With this mutant, higher product concentrations(36g DPA/l)could be reached without prior removal of Ca^<++> from the molasses. The DPA yields increased by about four times(0.4g DPA/g glucose consumed)and productivity by two and a half-times(3.0g DPA/l.d)compared with that of the parent strain 3114. Higher product yields(0.58-0.59g DPA/g glucose consumed)were obtained in a multiple stage fermentation system. DPA was recovered through separation by ion exchange chromatography followed by concentration and crystallization.

• 公益社団法人日本生物工学会の論文
• 1986-12-25

著者

• Kalle G.p.

  Hindustan Lever Research Center

• ADKAR S.S.

  Hindustan Lever Research Center

関連論文

• Continuous Fed-Batch Vacuum Fermentation System for Glycerol from Molasses by the Sulfite Process
• Fermentative Production of Dipicolinic Acid by Penicillium citreoviride from Sugarcane Molasses

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