Novel Actions of Inducer in Staphylomycin Production by Streptomyces virginiae : Physiological Studies on Staphylomycin Production by Streptomyces virginiae(IV)
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概要
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An inducer of staphylomycin production by Streptomyces virginiae(termed IM)was previously reported to have a molecular formula of C_<12>H_<22>O_4 which involved a γ-or δ-lactone group. The minimum concentration of partially purified IM for induction of staphylomycin production was 0.02 μg/ml which was defined as 1 unit/ml. In the present study, it was revealed that IM also showed a repressing action on staphylomycin production and product inhibition on its own formation. When 2 units/ml or more of IM was added to a culture at the early stage of growth(0 to 4h after inoculation), no staphylomycin was produced in the culture. This seemed to be caused by a repressing effect of IM on staphylomycin production. However, the repressing effect decreased gradually with a delay in the IM addition, being hardly affected by addition just prior to the initiation of staphylomycin production. On the other hand, when 4 units/ml or more of IM was added to a culture at 0 h or 8 h after inoculation, no further formation of IM was observed, though 32units/ml IM was produced in an IM-non-added culture. Further tests using replacement cultures were carried out. The results obtained were quantitatively expressed as a scheme. In order to elucidate the scheme, the concept of potentiality was introduced. Two paradoxical actions of IM are well explained by assuming that potentiality led to staphylomycin production by the inducing action of IM while the accumulation of potentiality is blocked by the repressing action of IM.
- 公益社団法人日本生物工学会の論文
- 1983-10-25