Production of the Macrolide Antibiotic Tylosin in Fed-batch Culture

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概要

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• Streptomyces fradiae was grown in batch culture on a defined medium. With this medium a growth associated kinetic pattern for the production of the macrolide antibiotic tylosin was obtained. The fermentation was characterized by high initial values of the specific production rate (q) of 1.9 mg tylosin synthesised/g dry wt/hr which decreased rapidly after 48 hr. Fed-batch fermentations were carried out with a linear feed of complete medium starting at 48 hr. The total tylosin synthesised was increased markedly in the fed-batch fermentations over that observed in the control, although the values of q observed were similar.

• 公益社団法人日本生物工学会の論文
• 1981-06-25

著者

• Gray P.p.

  School Of Biotechnology University Of New South Wales

• BHUWAPATHANAPUN S.

  Department of Food Science and Technology, Kasetsart University,

• Bhuwapathanapun S.

  Department Of Food Science And Technology Kasetsart University

関連論文

• Enzymic Hydrolysis of Bagasse Using a Counter Current plug Flow Reactor
• Production of the Macrolide Antibiotic Tylosin in Fed-batch Culture

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