Serum Concentrations of Vascular Endothelial Growth Factor and Monocyte-Colony Stimulating Factor in Peripheral Arterial Disease

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概要

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• Vascular endothelial growth factor (VEGF) strongly promotes angiogenesis, and monocyte-colony stimulating factor (M-CSF) regulates the differentiation, proliferation, and survival of monocytes. Both VEGF and M-CSF are expressed in atherosclerotic lesions. The present study was performed to clarify the role of VEGF and M-CSF in the development of peripheral artery disease (PAD). The serum VEGF and M-CSF concentrations were determined in patients with arteriosclerosis obliterans (ASO) and thromboangitis obliterans (TAO). In both patient groups the serum VEGF concentrations were significantly higher than those in the control subjects. In contrast, the serum M-CSF concentrations in the ASO patients were significantly higher than those in both the TAO patients and control subjects, but there were no differences in the M-CSF concentrations between the TAO patients and control subjects. There was no correlation between the serum concentrations of VEGF and M-CSF. In conclusion, the serum VEGF concentration was increased in ASO and TAO patients, but increased concentration of M-CSF was seen only in ASO patients. These results may reflect a difference between ASO and TAO in disease pathogenesis.

• 社団法人日本循環器学会の論文
• 2003-07-20

著者

• SHIMADA Kazuyuki

  Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical School

• Takahashi Masafumi

  Department Of Cardiovascular Medicine Shinshu University Graduate School Of Medicine

• IKEDA Uichi

  Department of Cardiovascular Medicine, Shinshu University Graduate School of Medicine

• Mitsuhashi Takeshi

  Department Of Cardiovascular Medicine Shinshu University Graduate School Of Medicine

• Matsui Keiji

  Division Of Cardiovascular Medicine Jichi Medical School

• Matsui Keiji

  Devision of Organ Replacement Research

• Yoshioka Toru

  Department of Organ Regeneration, Shinshu University Graduate School

• Murakami Yoshiaki

  Division of Cardiovascular Medicine, Jichi Medical School

• Shimada K

  Division Of Cardiovascular Medicine Department Of Medicine Jichi Medical University

• Yoshioka Tooru

  Division Of Cardiovascular Sciences Department Of Organ Regeneration Shinshu University Graduate Sch

• Maeda Yoshikazu

  Division Of Cardiovascular Medicine Department Of Medicine Jichi Medical School

• Ikeda Uichi

  Department Of Cardiology Jichi Medical School

• Yoshioka Tohru

  Department Of Cardiology Shinshu University School Of Medicine

• Yoshioka Toru

  Department Of Organ Regeneration Shinshu University Graduate School Of Medicine

• Shimada Kazuyuki

  Division Of Cardiology Department Of Medicine Jichi Medical University

• Murakami Yoshiaki

  Division Of Cardiovascular Medicine Jichi Medical School

• Yoshioka Toru

  Department Of Cardiology Shinshu University School Of Medicine

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