Coronary Microembolization

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概要

• 論文の詳細を見る

• Atherosclerotic plaque rupture is a key event in the pathogenesis of acute coronary syndromes and during coronary interventions.However,it does not always result in complete thrombotic occlusion of the entire epicardial coronary artery with subsequent acute myocardial infarction ; in milder forms the result can be embolization of atheroselerotic and thrombotic debris into the coronary microcirculation. This review summarizes the available morphological evidence for coronary microembolization in patients who died from coronary artery disease,most notably from sudden death,and then goes on to address the experimental pathophysiology of coronary microembolzation in animal models of acute coronary syndromes and heart failure. Finally,the review presents the avalable clinical evidence for coronary microembolization in patients,highlights its key features (ie,arrhythmias,contractile dysfunction,infarctlets and reduced coronary reserve) and addresses its prevention by mechanical protection devices and glycoprotein IIb/IIIa antagonism. (Circ J 2003 ; 67 : 279-286)

• 社団法人日本循環器学会の論文
• 2003-03-20

著者

• Heusch Gerd

  Abyeihoung Fur Kardiologie Zentrum Fur Lunere Medizin Iniversitatsklinkum

• Skyschally Andreas

  Instituf fur Pathophysiologie

• Erbel Raimund

  Instituf fur Pathophysiologie

関連論文

• Coronary Microembolization

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