Existence of α-Adrenoceptor Subtypes in Isolated Human Gastroepiploic and Omental Arteries
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概要
- 論文の詳細を見る
Establishing the existence of α-adrenoceptor subtypes in isolated human gastroepiploic and omental arteries was the goal of the present study. Functional vascular reactivity of selective α1- and α2-adrenoceptor agonists and antagonists was studied, using a cannula inserting technique. Intraluminal administration of norepinephrine (NE), phenylephrine (PE) or BHT-933 caused a vasoconstrictive response in a dose-related manner. The relative potencies of the 3 agonists were almost the same in both arteries. NE-induced vasoconstrictions were significantly antagonized by either prazosin or rauwolscine. PE-induced responses were strongly inhibited by prazosin. BHT-933-induced constrictions were inhibited by rauwolscine. These results indicate that both α1- and α2-adrenoceptors exist in the human gastroepiploic and omental arteries.
- 社団法人日本循環器学会の論文
- 2003-02-20
著者
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Fukui Daisuke
Department Of Cardiovascular Surgery Shishu University Of Medicine
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Fukui Daisuke
Department Of Surgery Shinshu University School Of Medicine
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Chiba Shigetoshi
Pharmacology, Shinshu University School of Medicine
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Chiba Shigetoshi
Pharmacology Shinshu University School Of Medicine
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